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class="expander fa fa-caret-right "></i><a class="" href="../17817/theoretical-genetics-1.html" title="Theoretical Genetics 1">Theoretical Genetics 1</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../23787/stargardt-disease.html" title="Stargardt disease">Stargardt disease</a></li></ul><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17818/theoretical-genetics-2.html" title="Theoretical Genetics 2">Theoretical Genetics 2</a></li><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17819/sex-linked-genes.html" title="Sex Linked Genes">Sex Linked Genes</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../17825/is-genetics-an-embarrassment-to-biology-education-.html" title="Is genetics an embarrassment to biology education? ">Is genetics an embarrassment to biology education? </a></li></ul><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17809/hairy-hands-genetics-of-mid-digital-hair.html" title="Hairy Hands - genetics of mid-digital hair">Hairy Hands - genetics of mid-digital hair</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17810/pedigree-chart-phenotype-ratios.html" title="Pedigree Chart & Phenotype Ratios">Pedigree Chart & Phenotype Ratios</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17820/ia-maize-genetics-experiment.html" title="IA Maize Genetics Experiment">IA Maize Genetics Experiment</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17823/genetically-modified-organisms.html" title="Genetically Modified Organisms.">Genetically Modified Organisms.</a></li><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17824/introduction-to-cloning.html" title="Introduction to Cloning.">Introduction to Cloning.</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../33736/cloning-ethics-quiz.html" title="Cloning ethics - quiz">Cloning ethics - quiz</a></li></ul><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17811/therapeutic-cloning-debate-.html" title="Therapeutic Cloning Debate ">Therapeutic Cloning Debate </a></li></ul><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../16981/ecology-activities-for-learning.html" title="Ecology Activities for Learning">Ecology Activities for Learning</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17905/ecological-terms.html" title="Ecological terms.">Ecological terms.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17906/food-webs.html" title="Food Webs">Food Webs</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17927/mesocosm-lab.html" title="Mesocosm Lab">Mesocosm Lab</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../23435/ecology-mini-investigation.html" title="Ecology mini investigation">Ecology mini investigation</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../33629/ecology-field-trip-at-home.html" title="Ecology field trip - at home">Ecology field trip - at home</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17907/energy-flow.html" title="Energy Flow.">Energy Flow.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17912/carbon-cycle-skills.html" title="Carbon Cycle Skills">Carbon Cycle Skills</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17908/enhanced-greenhouse-effect.html" title="Enhanced Greenhouse Effect.">Enhanced Greenhouse Effect.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17909/climate-change.html" title="Climate Change.">Climate Change.</a></li></ul><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../16985/evolution-activities-for-learning.html" title="Evolution: Activities for Learning">Evolution: Activities for Learning</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../15988/evolution-introduction.html" title="Evolution introduction">Evolution introduction</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../15990/variation-overproduction.html" title="Variation & overproduction">Variation & overproduction</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../15989/evolution-examples.html" title="Evolution examples">Evolution examples</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19320/classification-binomial-names.html" title="Classification & binomial names">Classification & binomial names</a></li><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../15991/classification-of-plants.html" title="Classification of Plants">Classification of Plants</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../19306/plant-classification-quiz.html" title="Plant classification quiz">Plant classification quiz</a></li></ul><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../15993/classification-of-animals.html" title="Classification of Animals">Classification of Animals</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../23751/classification-games.html" title="Classification games">Classification games</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18912/intro-to-cladistics.html" title="Intro to cladistics">Intro to cladistics</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18910/reclassification-of-figworts-using-cladistics.html" title="Reclassification of figworts using cladistics">Reclassification of figworts using cladistics</a></li></ul><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../18027/humans-activities-for-learning.html" title="Humans Activities for Learning">Humans Activities for Learning</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18028/digestion-enzymes-intro-.html" title="Digestion & Enzymes Intro ">Digestion & Enzymes Intro </a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18029/ia-lipase-experiment.html" title="IA Lipase Experiment">IA Lipase Experiment</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18033/structure-of-the-digestive-system.html" title="Structure of the digestive system.">Structure of the digestive system.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18030/intestine-structure-function.html" title="Intestine Structure & Function.">Intestine Structure & Function.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18031/blood-and-blood-vessels.html" title="Blood and Blood Vessels">Blood and Blood Vessels</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18032/heart-dissection-diagram.html" title="Heart Dissection & Diagram">Heart Dissection & Diagram</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18026/controlling-heartbeat.html" title="Controlling Heartbeat">Controlling Heartbeat</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18590/blood-clotting-and-heart-disease.html" title="Blood clotting and heart disease.">Blood clotting and heart disease.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18117/antigens-and-antibodies-.html" title="Antigens and antibodies ">Antigens and antibodies </a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18180/hiv-and-aids.html" title="HIV and AIDS">HIV and AIDS</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18116/immune-system-.html" title="Immune System ">Immune System </a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18115/alveoli-gas-exchange.html" title="Alveoli & gas exchange">Alveoli & gas exchange</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19330/ventilation-lung-disease.html" title="Ventilation & lung disease">Ventilation & lung disease</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18421/nerve-impulses.html" title="Nerve impulses.">Nerve impulses.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18461/synapses.html" title="Synapses">Synapses</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../31311/chemicals-which-affect-synapses.html" title="Chemicals which affect synapses">Chemicals which affect synapses</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19886/hormones-introduction.html" title="Hormones introduction">Hormones introduction</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19894/homeostasis-of-glucose.html" title="Homeostasis of Glucose.">Homeostasis of Glucose.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19907/harvey-and-the-search-for-ova.html" title="Harvey and the search for ova">Harvey and the search for ova</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19908/hormones-and-the-menstrual-cycle.html" title="Hormones and the menstrual cycle">Hormones and the menstrual cycle</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19927/hormones-in-ivf.html" title="Hormones in IVF">Hormones in IVF</a></li></ul></ul><li class="ancestor parent std-toplevel" style="padding-left: 4px"><i class="expander fa fa-caret-right fa-rotate-90"></i><a class="" href="../17178/additional-hl.html" title="Additional HL">Additional HL</a></li><ul class="level-1 expanded"><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../17917/hl-nucleic-acids-activities-for-learning.html" title="HL Nucleic Acids Activities for Learning">HL Nucleic Acids Activities for Learning</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17918/dna-structure-extras-for-hl.html" title="DNA structure - Extras for HL">DNA structure - Extras for HL</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../16141/dna-replication-for-hl-students.html" title="DNA Replication for HL Students">DNA Replication for HL Students</a></li><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17920/transcription-extras-for-hl.html" title="Transcription - extras for HL">Transcription - extras for HL</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../37259/extension-concept-hydrolysis-of-atp.html" title="Extension concept - Hydrolysis of ATP">Extension concept - Hydrolysis of ATP</a></li></ul><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18048/translation-ribosomes.html" title="Translation & ribosomes">Translation & ribosomes</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17921/four-levels-of-protein-structure.html" title="Four levels of protein structure">Four levels of protein structure</a></li></ul><li class="ancestor parent" style="padding-left: 14px"><i class="expander fa fa-caret-right fa-rotate-90"></i><a class="" href="../18211/hl-metabolism-activities-for-learning.html" title="HL Metabolism Activities for Learning">HL Metabolism Activities for Learning</a></li><ul class="level-2 expanded"><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19840/activation-energy-and-enzyme-pathways.html" title="Activation energy and enzyme pathways">Activation energy and enzyme pathways</a></li><li class="ancestor parent" style="padding-left: 28px"><i class="expander fa fa-caret-right fa-rotate-90"></i><a class="" href="../19850/emergency-room-activity-enzyme-inhibition.html" title="Emergency room activity - enzyme inhibition">Emergency room activity - enzyme inhibition</a></li><ul class="level-3 expanded"><li class="current" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="toxicology-training-course.html" title="Toxicology training course">Toxicology training course</a></li></ul><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17923/end-product-inhibition-of-enzymes.html" title="End product inhibition of Enzymes.">End product inhibition of Enzymes.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17922/hl-respiration-introduction.html" title="HL Respiration introduction">HL Respiration introduction</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../16207/glycolysis-and-the-krebs-cycle.html" title="Glycolysis and the Krebs Cycle">Glycolysis and the Krebs Cycle</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18214/electron-transport-chain.html" title="Electron transport chain">Electron transport chain</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../16209/chloroplasts-and-photosynthesis.html" title="Chloroplasts and Photosynthesis">Chloroplasts and Photosynthesis</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../16210/light-dependent-reactions.html" title="Light Dependent Reactions">Light Dependent Reactions</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../16211/light-independent-reactions.html" title="Light Independent Reactions">Light Independent Reactions</a></li></ul><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../17720/hl-plant-biology-activities-for-learning.html" title="HL Plant Biology - Activities for Learning">HL Plant Biology - Activities for Learning</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17726/leaf-stomata-transpiration.html" title="Leaf stomata & transpiration">Leaf stomata & transpiration</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17721/vascular-tissues-introduction.html" title="Vascular tissues - introduction">Vascular tissues - introduction</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17723/transport-in-xylem.html" title="Transport in xylem">Transport in xylem</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17727/experiments-on-transpiration.html" title="Experiments on Transpiration.">Experiments on Transpiration.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17724/transpiration-and-xerophytes-.html" title="Transpiration and Xerophytes ">Transpiration and Xerophytes </a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17763/phloem-and-translocation.html" title="Phloem and translocation">Phloem and translocation</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17722/meristems-and-growth.html" title="Meristems and Growth.">Meristems and Growth.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17804/hormonal-control-in-plants.html" title="Hormonal control in plants">Hormonal control in plants</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17725/reproduction-in-angiosperms.html" title="Reproduction in angiosperms.">Reproduction in angiosperms.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17808/seeds-flowering-phytochromes.html" title="Seeds, flowering & phytochromes">Seeds, flowering & phytochromes</a></li></ul><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../17888/hl-genetics-activities-for-learning.html" title="HL Genetics Activities for Learning">HL Genetics Activities for Learning</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17889/meiosis.html" title="Meiosis.">Meiosis.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17890/di-hybrid-crosses.html" title="Di-Hybrid Crosses.">Di-Hybrid Crosses.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17892/polygenic-inheritance.html" title="Polygenic Inheritance.">Polygenic Inheritance.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17891/gene-linkage-1.html" title="Gene Linkage 1">Gene Linkage 1</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17894/gene-linkage-2.html" title="Gene Linkage 2">Gene Linkage 2</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17901/gene-pools.html" title="Gene pools">Gene pools</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19670/polyploidy.html" title="Polyploidy">Polyploidy</a></li></ul><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../19559/hl-animal-physiology-activities-for-learning.html" title="HL Animal Physiology Activities for Learning">HL Animal Physiology Activities for Learning</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19560/antibody-production.html" title="Antibody production">Antibody production</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19566/monoclonal-antibodies.html" title="Monoclonal antibodies">Monoclonal antibodies</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19565/vaccination.html" title="Vaccination">Vaccination</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19561/muscles-joints.html" title="Muscles & joints">Muscles & joints</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19564/muscle-structure-function.html" title="Muscle structure & function.">Muscle structure & function.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19681/osmoregulation.html" title="Osmoregulation">Osmoregulation</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19562/kidney-and-nephrons.html" title="Kidney and nephrons.">Kidney and nephrons.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18813/gamete-formation.html" title="Gamete formation">Gamete formation</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../16365/fertilization-blastocyst.html" title="Fertilization & blastocyst">Fertilization & blastocyst</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20080/pregnancy-and-birth.html" title="Pregnancy and birth">Pregnancy and birth</a></li></ul></ul><li class=" parent std-toplevel" style="padding-left: 4px"><i class="expander fa fa-caret-right "></i><a class="" href="../17193/options-.html" title="Options ">Options </a></li><ul class="level-1 "><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../21490/option-a-neurobiology-activities-for-learning.html" title="Option A - Neurobiology - Activities for learning">Option A - Neurobiology - Activities for learning</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../21399/nervous-system-formation.html" title="Nervous system formation">Nervous system formation</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../21401/synapses-and-nervous-system-plasticity.html" title="Synapses and nervous system plasticity">Synapses and nervous system plasticity</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../21519/brain-structure-and-function.html" title="Brain structure and function">Brain structure and function</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../21520/the-cerebral-cortex.html" title="The Cerebral cortex">The Cerebral cortex</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../21525/sensory-receptors-and-smell.html" title="Sensory receptors and smell">Sensory receptors and smell</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../21526/the-eye-and-photoreceptors.html" title="The eye and photoreceptors">The eye and photoreceptors</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../33371/reflexes.html" title="Reflexes">Reflexes</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../33372/conditioning-and-imprinting.html" title="Conditioning and imprinting">Conditioning and imprinting</a></li></ul><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../25280/option-b-biotechnology-and-bioinformatics.html" title="Option B - Biotechnology and bioinformatics">Option B - Biotechnology and bioinformatics</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../32571/batch-fermentation-and-continuous-culture.html" title="Batch fermentation and continuous culture">Batch fermentation and continuous culture</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../25411/cryptic-messages-bioinformatics-introduction.html" title="Cryptic messages - bioinformatics introduction">Cryptic messages - bioinformatics introduction</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../25364/orf-activity.html" title="ORF activity">ORF activity</a></li></ul><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../22063/option-c-ecology-activities-for-learning.html" title="Option C - Ecology Activities for learning">Option C - Ecology Activities for learning</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../22081/describing-communities.html" title="Describing communities">Describing communities</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../22083/limits-and-zones-lab.html" title="Limits and zones lab">Limits and zones lab</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../22084/symbiosis-v-competitive-exclusion.html" title="Symbiosis v Competitive exclusion">Symbiosis v Competitive exclusion</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../22085/modelling-energy-flow.html" title="Modelling energy flow">Modelling energy flow</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../22086/predicting-ecosystems.html" title="Predicting ecosystems">Predicting ecosystems</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../22089/modelling-nutrients.html" title="Modelling nutrients">Modelling nutrients</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../22088/disturbance-vs-diversity.html" title="Disturbance vs Diversity">Disturbance vs Diversity</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../22807/invasive-species.html" title="Invasive species">Invasive species</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../22810/biomagnification.html" title="Biomagnification">Biomagnification</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../22958/plastic-debris.html" title="Plastic debris">Plastic debris</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../23153/indicator-species-biotic-index.html" title="Indicator species & biotic index">Indicator species & biotic index</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../23154/conservation-methods.html" title="Conservation methods">Conservation methods</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../22059/biodiversity-estimations.html" title="Biodiversity estimations">Biodiversity estimations</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../22060/lincoln-index-activities.html" title="Lincoln Index activities">Lincoln Index activities</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../27387/population-growth-curves.html" title="Population growth curves">Population growth curves</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../27433/fisheries-and-populations.html" title="Fisheries and populations">Fisheries and populations</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18998/nitrogen-cycle-applications.html" title="Nitrogen cycle - applications">Nitrogen cycle - applications</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../28235/phosphorus-cycle.html" title="Phosphorus cycle">Phosphorus cycle</a></li></ul><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../20088/option-d-human-physiology-activities-for-learning.html" title="Option D - Human physiology Activities for learning">Option D - Human physiology Activities for learning</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20215/is-it-so-bad-to-eat-only-pizza.html" title="Is it so bad to eat only pizza?">Is it so bad to eat only pizza?</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20220/appetite-and-malnutrition.html" title="Appetite and malnutrition">Appetite and malnutrition</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20284/exocrine-glands.html" title="Exocrine glands">Exocrine glands</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20300/control-of-digestive-secretions.html" title="Control of digestive secretions">Control of digestive secretions</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20259/a-miracle-cure-for-ulcers.html" title="A miracle cure for ulcers">A miracle cure for ulcers</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20664/liver-structure-function.html" title="Liver structure & function.">Liver structure & function.</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20665/jaundice-liver-function.html" title="Jaundice & liver function">Jaundice & liver function</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20692/cardiac-muscle-myogenic-control.html" title="Cardiac muscle & myogenic control">Cardiac muscle & myogenic control</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20707/cardiology-role-play.html" title="Cardiology Role play">Cardiology Role play</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../24113/epidemiology-framingham-heart-study.html" title="Epidemiology - Framingham heart study">Epidemiology - Framingham heart study</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20706/pituitary-gland-and-hormones.html" title="Pituitary gland and hormones">Pituitary gland and hormones</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20732/oxygen-dissociation-curves.html" title="Oxygen dissociation curves">Oxygen dissociation curves</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20708/carbon-dioxide-and-bohr-shift.html" title="Carbon dioxide and Bohr shift">Carbon dioxide and Bohr shift</a></li></ul></ul><li class=" parent std-toplevel" style="padding-left: 4px"><i class="expander fa fa-caret-right "></i><a class="" href="../17622/the-investigation.html" title="The Investigation">The Investigation</a></li><ul class="level-1 "><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../21187/individual-investigation-skills-introduction.html" title="Individual investigation - skills introduction">Individual investigation - skills introduction</a></li><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../17179/practical-scheme-of-work.html" title="Practical Scheme of Work">Practical Scheme of Work</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../16860/lab-protocols-for-the-biology-ib-guide.html" title="Lab protocols for the Biology IB guide">Lab protocols for the Biology IB guide</a></li></ul><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../17623/planning-for-skills-progression.html" title="Planning for skills progression">Planning for skills progression</a></li><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../17624/personal-engagement.html" title="Personal Engagement">Personal Engagement</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19063/personal-engagement-personality-quiz.html" title="Personal Engagement - personality quiz">Personal Engagement - personality quiz</a></li></ul><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../34461/three-ways-to-choose-a-topic-for-the-ia.html" title="Three ways to choose a topic for the IA">Three ways to choose a topic for the IA</a></li><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../17625/exploration.html" title="Exploration">Exploration</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../23429/focusing-a-research-question.html" title="Focusing a research question">Focusing a research question</a></li></ul><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../17626/analysis.html" title="Analysis">Analysis</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../26255/ia-analysis-anova-or-t-test.html" title="IA Analysis - ANOVA or t-test?">IA Analysis - ANOVA or t-test?</a></li></ul><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../17627/evaluation.html" title="Evaluation">Evaluation</a></li><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../17628/communication.html" title="Communication">Communication</a></li><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../38973/ia-ideas-during-a-pandemic-2020-21.html" title="IA ideas during a pandemic 2020-21">IA ideas during a pandemic 2020-21</a></li><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../30218/ia-avoiding-common-errors.html" title="IA - Avoiding common errors">IA - Avoiding common errors</a></li><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../34356/ia-experiments-that-could-be-done-at-home.html" title="IA Experiments that could be done at home">IA Experiments that could be done at home</a></li><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../34574/ia-experiment-ideas-inspired-by-youtube.html" title="IA experiment ideas inspired by Youtube">IA experiment ideas inspired by Youtube</a></li><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../15992/6-ecological-ideas-for-your-ia.html" title="6 Ecological ideas for your IA">6 Ecological ideas for your IA</a></li><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../20852/30-investigation-ideas-for-biology-ia.html" title="30 investigation ideas for Biology IA">30 investigation ideas for Biology IA</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../39689/investigating-strawberries-with-a-glucose-test-meter.html" title="Investigating strawberries with a glucose test meter">Investigating strawberries with a glucose test meter</a></li></ul><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../23240/16-new-experiment-ideas-for-biology-ia.html" title="16 new experiment ideas for Biology IA">16 new experiment ideas for Biology IA</a></li><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../26171/12-investigation-ideas-with-a-biological-twist.html" title="12 Investigation ideas with a biological twist.">12 Investigation ideas with a biological twist.</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../26186/body-temperature-data.html" title="Body temperature data">Body temperature data</a></li></ul><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../19329/ia-investigation-marking-sheet.html" title="IA Investigation - marking sheet">IA Investigation - marking sheet</a></li><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../21859/marking-rigour-ia-assessment-criteria.html" title="Marking rigour & IA assessment criteria.">Marking rigour & IA assessment criteria.</a></li></ul><li class=" parent std-toplevel" style="padding-left: 4px"><i class="expander fa fa-caret-right "></i><a class="" href="../18404/quizzes-tests-revision.html" title="Quizzes tests & revision">Quizzes tests & revision</a></li><ul class="level-1 "><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../17665/the-exams.html" title="The Exams">The Exams</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19051/describing-trends-in-ib-graphs.html" title="Describing trends in IB graphs">Describing trends in IB graphs</a></li><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20791/paper-3-section-a-questions.html" title="Paper 3 Section A - questions">Paper 3 Section A - questions</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../26073/graphical-analysis-skills-for-life.html" title="Graphical analysis - skills for life!">Graphical analysis - skills for life!</a></li></ul></ul><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../18403/a3-topic-revision-sheets.html" title="A3 topic revision sheets">A3 topic revision sheets</a></li><ul class="level-2 "><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18405/topic-1-cells-revision-activities.html" title="Topic 1 - Cells revision activities">Topic 1 - Cells revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../22372/topic-1-cells-sl-revision-list.html" title="Topic 1 - Cells SL revision list">Topic 1 - Cells SL revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19003/topic-2-molecular-biology-revision-activities.html" title="Topic 2 - Molecular biology revision activities">Topic 2 - Molecular biology revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../22373/topic-2-bio-molecules-sl-revision-list.html" title="Topic 2 - Bio molecules SL revision list">Topic 2 - Bio molecules SL revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18999/topic-3-genetics-sl-revision-activities.html" title="Topic 3 - Genetics SL revision activities">Topic 3 - Genetics SL revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../22378/topic-3-genetics-sl-revision-list.html" title="Topic 3 - Genetics SL revision list">Topic 3 - Genetics SL revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19480/topic-4-ecology-sl-revision-activities.html" title="Topic 4 - Ecology SL revision activities">Topic 4 - Ecology SL revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../22395/topic-4-ecology-revision-list.html" title="Topic 4 - Ecology revision list">Topic 4 - Ecology revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19006/topic-5-evolution-sl-revision-activities.html" title="Topic 5 - Evolution SL revision activities">Topic 5 - Evolution SL revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../22474/topic-5-evolution-revision-list.html" title="Topic 5 - Evolution revision list">Topic 5 - Evolution revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20121/topic-6-human-physiology-sl-revision-activities.html" title="Topic 6 - human physiology SL revision activities">Topic 6 - human physiology SL revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../22396/topic-6-human-physiology-revision-list.html" title="Topic 6 - Human physiology revision list">Topic 6 - Human physiology revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20196/topic-7-nucleic-acids-hl-revision-activities.html" title="Topic 7 - Nucleic acids HL revision activities">Topic 7 - Nucleic acids HL revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../20139/topic-7-nucleic-acids-hl-revision-list.html" title="Topic 7 - Nucleic acids HL revision list">Topic 7 - Nucleic acids HL revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20787/topic-8-metabolism-hl-revision-activities.html" title="Topic 8 - Metabolism HL revision activities">Topic 8 - Metabolism HL revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../20198/topic-8-metabolism-hl-revision-list.html" title="Topic 8 - Metabolism HL revision list">Topic 8 - Metabolism HL revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20122/topic-9-plant-biology-hl-revision-activities.html" title="Topic 9 - Plant biology HL revision activities">Topic 9 - Plant biology HL revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../20773/topic-9-plants-hl-revision-list.html" title="Topic 9 - Plants HL - revision list">Topic 9 - Plants HL - revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../20849/topic-10-genetics-hl-revision-activities.html" title="Topic 10 - Genetics HL Revision activities">Topic 10 - Genetics HL Revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../20128/topic-10-genetics-hl-revision-list.html" title="Topic 10 - Genetics HL revision list">Topic 10 - Genetics HL revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="std-disabled" href="#" title="Topic 11 - Physiology HL Revision activities">Topic 11 - Physiology HL Revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../20115/topic-11-animal-physiology-revision-list.html" title="Topic 11 - Animal physiology revision list">Topic 11 - Animal physiology revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../23821/option-a-neurobiology-revision-activities.html" title="Option A - Neurobiology - Revision activities">Option A - Neurobiology - Revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../23822/option-a-neurobiology-sl-revision-list.html" title="Option A - Neurobiology SL Revision list">Option A - Neurobiology SL Revision list</a></li><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../23831/option-a-neurobiology-hl-revision-list.html" title="Option A - Neurobiology HL Revision list">Option A - Neurobiology HL Revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../19001/option-c-ecology-revision-activities.html" title="Option C - Ecology revision activities">Option C - Ecology revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../27865/option-c-ecology-sl-revision-list-.html" title="Option C - Ecology SL revision list ">Option C - Ecology SL revision list </a></li><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../27863/option-c-ecology-hl-revision-list.html" title="Option C - Ecology HL revision list">Option C - Ecology HL revision list</a></li></ul><li class=" parent" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../26107/option-d-human-physiology-revision-activities.html" title="Option D - Human Physiology Revision activities">Option D - Human Physiology Revision activities</a></li><ul class="level-3 "><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../26108/option-d-human-physiology-hl-revision-list.html" title="Option D - Human physiology HL revision list">Option D - Human physiology HL revision list</a></li><li class="" style="padding-left: 42px"><i class="expander fa fa-caret-right "></i><a class="" href="../27855/option-d-human-physiology-sl-revision-list.html" title="Option D - Human physiology SL Revision list">Option D - Human physiology SL Revision list</a></li></ul></ul><li class="" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../17996/multiple-choice-quizzes.html" title="Multiple Choice Quizzes">Multiple Choice Quizzes</a></li><li class=" parent" style="padding-left: 14px"><i class="expander fa fa-caret-right "></i><a class="" href="../17664/key-biological-terms-by-topic.html" title="Key biological terms - by topic">Key biological terms - by topic</a></li><ul class="level-2 "><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17670/key-terms-cells-topic.html" title="Key terms - Cells topic">Key terms - Cells topic</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../17671/key-terms-molecular-biology-topic.html" title="Key terms - Molecular biology topic">Key terms - Molecular biology topic</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" href="../18209/key-terms-genetics-sl-topic.html" title="Key terms - Genetics SL topic">Key terms - Genetics SL topic</a></li><li class="" style="padding-left: 28px"><i class="expander fa fa-caret-right "></i><a class="" 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<div id="main-column" class="span9"> <article id="toxicology-training-course" style="margin-top: 16px;">
<h1 class="section-title">Toxicology training course</h1>
<ul class="breadcrumb"><li><a title="Home" href="../../../biology.html"><i class="fa fa-home"></i></a><span class="divider">/</span></li><li><span class="gray">Additional HL</span><span class="divider">/</span></li><li><span class="gray">HL Metabolism Activities for Learning</span><span class="divider">/</span></li><li><span class="gray">Emergency room activity - enzyme inhibition</span><span class="divider">/</span></li><li><span class="active">Toxicology training course</span></li></ul>
<div class="row-fluid">
<section class="span12" id="main-content">
<h3 class="section-title">Emergency room training activity - enzyme inhibition</h3>
<p>Read the following medical briefing sheets - imagine that you are a junior doctor doing a toxicology course.</p>
<p>Answer the questions at the end of each section and keep brief notes for yourself.</p>
<div class="tib-quiz" data-quiz-id="69" data-structure="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" data-score-answers="6d4a526a457a48584f763758344a7649472f76324c53614b78524c393439595570496d5a5971374b38686f3d"><div class="exercise">
<h3>Alcohol metabolism, enyzyme inhibition & toxicology </h3>
<div class="q-question">This short training course will help you to understand the metabolic pathway for both alcohol metabolism and also for the metabolism of ethylene glycol (antifreeze). This is a dangerous poison which is sometimes ingested accidentally and which can be fatal if untreated. If you know about enzyme inhibitors then there are effective treatments.
<p><img alt="" src="../../../ib/biology/emergency-room-image.jpg" style="width: 286px; height: 253px; float: left;"><strong>.</strong></p>
<p><strong>.</strong></p>
<p><strong>Course contents</strong></p>
<ul>
<li>Introduction to alcohol metabolism</li>
<li>Symptoms of alcohol intoxication</li>
<li>Ethylene glycol metabolism</li>
<li>Symptoms of intoxication</li>
<li>Treatment option 1 - using a competitive inhibitors of an enzyme</li>
<li>Treatment option 2 - using a non-competitive inhibitor</li>
<li>Treatment option 3 - dialysis</li>
</ul>
<p>.</p>
<p>.</p>
<p>After each section there is a self-review question. Answer this question correctly before continuing.</p>
<p>Test yourself now to see if you are ready to begin this course.</p>
<p><u><strong>Question 1</strong></u></p>
<p>Which is the best description of a cell's metabolism?</p>
</div>
<div class="q-answer">
<p><label class="radio" data-answer="8120301f3fa5a19f3794bf9f98d007f2"><input type="radio"><span> enzyme catalysed reactions which are anabolic</span></label></p>
<p><label class="radio" data-answer="2fb852049d1ce9d5f717bb4d79afae87"><input type="radio"><span> chains and cycles of enzyme catalysed reactions</span></label></p>
<p><label class="radio" data-answer="483961669ef6a1ae7026c84670a9feda"><input type="radio"><span>enzyme catalysed reactions which are exothermic</span></label></p>
<p><label class="radio" data-answer="cc842f6efb30d7f213b76a2960b2bad2"><input type="radio"><span> chains and cycles of proteins in the cytoplasm</span></label></p>
</div>
<div class="q-explanation">
<p><span style="color:#FF0000;">If you answered correctly, Well done. If not, review the key information you didn't know. </span></p>
</div>
<div class="actions"><span class="score" data-score="0"></span><button class="btn check"><i class="fa fa-check-square-o"></i> Check</button></div></div>
<p> </p>
<div class="exercise">
<div class="q-question">
<h3><strong>Introduction to alcohol metabolism & Symptoms of alcohol intoxication</strong></h3>
<p>The metabolic pathway of alcohol metabolism begins in the liver with the enzyme, "alcohol dehydrogenase" this enzyme produces acetaldehyde which is the substrate for the second enzyme in the pathway, "acetaldehyde dehydrogenase".</p>
<p><img alt="" src="../../../ib/biology/images/flickr_cc_commercial_ok/hl_topics/08_metabolism/alcohol_metabolism_liver_smaller.jpg" style="width: 720px; height: 405px;"></p>
<p>The alcohol leads to symptoms such as</p>
<ul>
<li>Reduced inhibition in social situations</li>
<li>Excessive talking, showing off</li>
<li>Ataxia (reduced coordination)</li>
<li>Loss of memory</li>
<li>Slurred speech</li>
<li>Vomiting</li>
</ul>
<p>The acetaldehyde produced is largely responsible for the hangover symptoms which occur 12-24 hours after alcohol intoxication.</p>
<p>Both these dehydrogenase enzymes remove hydrogen from their substrates which is carried by reduced NAD (NADH + H<sup>+</sup>)</p>
<p>This acetic acid produced by acetaldehyde dehydrogenase is converted into acetyl-co A which enters the krebs cycle in mitochondria of the liver.</p>
<p>Some alcohol is excreted by the lungs (5%) or the kidneys (5%) and can be tested for in breath of in the urine.</p>
<p><u><strong>Question 2</strong></u> </p>
<p>What is the name of the first enzyme in alcohol metabolism?</p>
</div>
<div class="q-answer">
<p><label class="radio" data-answer="b19bcfc46e28afe7502d5f60bd1c7218"><input type="radio"><span> alcohol dehydrogenase</span></label></p>
<p><label class="radio" data-answer="85e8e587bb157b69e68ae2480dd06076"><input type="radio"><span> acetaldehyde dehydrogenase</span></label></p>
<p><label class="radio" data-answer="8ba1f411b07dc13d51608811de7d2ef4"><input type="radio"><span> reduced NAD</span></label></p>
<p><label class="radio" data-answer="4b5929de57fc0756a25d46d9c09f9350"><input type="radio"><span> acetyl co-A synthase</span></label></p>
</div>
<div class="q-explanation">
<p><span style="color:#FF0000;">If you answered correctly, Well done. If not, please review the key information you didn't know before continuing.</span></p>
</div>
<div class="actions"><span class="score" data-score="0"></span><button class="btn check"><i class="fa fa-check-square-o"></i> Check</button></div></div>
<div class="exercise">
<div class="q-question">
<h3><strong>Ethylene glycol metabolism & symptoms of intoxication</strong><img alt="" src="../../../ib/biology/images/flickr_cc_commercial_ok/hl_topics/11humans/ethanol_ethyleneglycol_molecules_small.jpg" style="width: 350px; height: 177px; float: right;"></h3>
<p><br>
Ethylene glycol is a clear, colorless, odorless, sweet-tasting liquid.</p>
<p>Ethylene glycol, HOCH<sub>2</sub>CH<sub>2</sub>OH has a chemical structures similar to ethanol, CH<sub>3</sub>CH<sub>2</sub>OH</p>
<p>Ethylene glycol is rapidly absorbed from the intestines within 30-60 minutes following ingestion. It is water soluble.</p>
<p>The toxicity of ethylene glycol results from its metabolism, catalysed by enzymes in the liver, which produce more toxic chemicals. </p>
<p>This metabolic pathway breaks down ethylene glycol quickly in the body (in a few hours) into glycoaldehyde, then into acids which change blood pH and oxalic acid which reacts with calcium to form calcium oxalate crystals which damage heart, lung and blood vessel tissues. </p>
<p style="text-align: center;"><img alt="" src="../../../ib/biology/images/flickr_cc_commercial_ok/hl_topics/11humans/ethylene_glycol_liver_smaller.jpg" style="width: 700px; height: 306px;"></p>
<p>Symptoms or ethylene-glycol intoxication are at first similar to alcholol intoxication.</p>
<ul>
<li>ataxia (reduced coordination)</li>
<li>sleepiness</li>
<li>slurred speech</li>
</ul>
<p>Once glycoaldehyde begins to form the CNS can be severly depressed leading to</p>
<ul>
<li>siezure - where electrical activity in the brain changes</li>
<li>vomiting</li>
</ul>
<p>Symptoms of the later metabolic products are often;</p>
<ul>
<li>fluid on the lungs or lung inflamation leading to rapid breathing (hyperventilation)</li>
<li>heart problems leading to rapid heart rate</li>
<li>problems in blood vessels leading to changes in blood pressure (higher or lower)</li>
</ul>
<p>In serious intoxication the symptoms above are often fatal, but if not, calcium oxalate crystals form in the kidney tubules at later stages causing kidney failure.</p>
<p><strong>Question 3</strong></p>
<p>Why is ethylene glycol so much more dangerous than alcohol?</p>
</div>
<div class="q-answer">
<p><label class="radio" data-answer="9e829ba6b510fdbf0d858cab816f429d"><input type="radio"><span> It is broken down into toxic products during its metabolism</span></label></p>
<p><label class="radio" data-answer="9a2d23e7fce86352a0756af33b1167cc"><input type="radio"><span> Only a low percentage is excreted in urine</span></label></p>
<p><label class="radio" data-answer="e8689967a5dd9a6bb597c18c12d3fa5b"><input type="radio"><span> It damages the enzyme alcohol dehydrogenase in the liver</span></label></p>
<p><label class="radio" data-answer="7f2572320b532e6bfffd4044b130d080"><input type="radio"><span> It has an extra OH group compared to ethanol</span></label></p>
</div>
<div class="q-explanation">
<p><span style="color:#FF0000;">If you answered correctly, Well done. If not, please review the key information you didn't know before continuing.</span></p>
</div>
<div class="actions"><span class="score" data-score="0"></span><button class="btn check"><i class="fa fa-check-square-o"></i> Check</button></div></div>
<div class="exercise">
<div class="q-question">
<h3><strong>Treatment option 1 - using Ethanol as a competitive inhibitors of an enzyme</strong></h3>
<p>The most important way to prevent poisoning by the metabolic products of ethylene glycol is to stop their production.</p>
<p><img alt="" src="../../../ib/biology/images/flickr_cc_commercial_ok/hl_topics/11humans/alcohol_dehydrogenase_ethyleneglycol.jpg" style="width: 300px; height: 135px; float: left;">To do this we need to inhibit the action of the enzyme alcohol dehydrogenase. This is the enzyme which starts the metabolism.</p>
<p>Remember that the ethylene glycol first has to bind to the active site of the enzyme. Hydrogen is removed and the products are released.</p>
<p>One way to stop the ethylene glycol from binding to the active site is to fill the active site with a different molecule which also fits into the active site .... like ethanol.</p>
<p>Ethanol is a <strong>competitive inhibitor </strong>in this case - it competes with the substrate (ethylene glycol) for the active site of the enzyme</p>
<p>Ethanol reacts in the same way, but doesn't produce the same toxic metabolic <img alt="" src="../../../ib/biology/images/flickr_cc_commercial_ok/hl_topics/11humans/alcohol_dehydrogenase_action.jpg" style="width: 300px; height: 147px; float: left;">products. </p>
<p>One treatment option is to keep the patients blood ethanol level raised for three days. This slows down the breakdown of ethylene glycol which gives more time for the body to excrete the unchanged ethylene glycol by the kidneys.</p>
<p>Of course there are problems because the ethanol level needs monitoring, and the patient will be 'drunk' for three days.</p>
<p>.</p>
<p>Competitive inhibition reduces a reaction rate by preventing the substrate from binding to the active site. <br>
The higher the concentration the more inhibition there is.</p>
<p> </p>
<p><strong>Question 4</strong></p>
<p>Which is the best definition of a competitive inhibitor?</p>
</div>
<div class="q-answer">
<p><label class="radio" data-answer="4d2109ed53f87a0fc1aa3e27d08804c2"><input type="radio"><span> The inhibitor binds to the active site of the enzyme preventing the products from being released</span></label></p>
<p><label class="radio" data-answer="d6f4aac433c8c6e59aaff38ea676d1fc"><input type="radio"><span> The inhibitor competes with the enzyme to bind with the substrate</span></label></p>
<p><label class="radio" data-answer="1f53664a37aec1d921b29092b234df75"><input type="radio"><span> The inhibitor reacts with the substrate preventing it from binding to the active site.</span></label></p>
<p><label class="radio" data-answer="289fc78e2afb8488dba81f053fffe4f5"><input type="radio"><span> The inhibitor binds to the active site of an enzyme preventing the substrate from binding</span></label></p>
</div>
<div class="q-explanation">
<p><span style="color:#FF0000;">If you answered correctly, Well done. If not, please review the key information you didn't know before continuing.</span></p>
</div>
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<div class="exercise">
<div class="q-question">
<h3><strong>Treatment option 2 - a new competitive inhibitor "Fomezipole"</strong></h3>
<h3><img alt="" src="../../../ib/biology/images/flickr_cc_commercial_ok/hl_topics/11humans/alcohol_dehy_fomezipole_action.jpg" style="width: 200px; height: 294px; float: left;"></h3>
<p>For detailed information about this medicine see the <a href="http://www.drugs.com/pro/fomepizole.html" target="_blank">Drugs.com database</a></p>
<p>This medicine acts as a competitive inhibotor of the alcohol dehydrogenase enzyme and slows the production of the toxic metabolic products, just like ethanol.</p>
<p>It has several advantages:</p>
<ul>
<li>is easier to use clinically and requires less monitoring</li>
<li>has a slower rate of elimination</li>
<li>has a longer duration of action</li>
<li>has a reasonable dosing schedule</li>
<li>has less potential for adverse effects</li>
<li>does not cause CNS depression or hypoglycemia</li>
<li>avoids problems in patient care, such as drunkenness</li>
</ul>
<p><strong>Disadvantages</strong></p>
<p>One disadvantage is that fomepizole is more expensive than ethanol treatment.</p>
<p>.</p>
<p><u><strong>Question 6</strong></u></p>
<p>What is the main similarity between Fomepizole and ethanol? </p>
</div>
<div class="q-answer">
<p><label class="radio" data-answer="28a0a683ba1301d1c3ed915bfceca73c"><input type="radio"><span> Both fompizole and ethanol act as competitive inhibitors of alcohol dehydrogenase </span></label></p>
<p><label class="radio" data-answer="7faf5bed0603fe07a8d01f9f4c52f474"><input type="radio"><span> Both ethanol and fomepizole cause drunkenness </span></label></p>
<p><label class="radio" data-answer="b591efe0314a5f4b50d01e35adde973f"><input type="radio"><span> Both are metabolised by alcohol dehydrogenase</span></label></p>
<p><label class="radio" data-answer="dbb7481cd3ddbf0c30ae8b9d42e9fad1"><input type="radio"><span> Both fompizole and ethanol act as competitive inhibitors of ethylene glycol</span></label></p>
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<h3><strong>Treatment option 3 - dialysis</strong></h3>
<p>If the concentration of ethylene glycol is very high in the blood it is essential to remove some of this as quickly as possible. To do this the patient can have a treatment of dialysis. The ethylene glycol will diffuse across the dialysis membrane.</p>
<p><u><strong>Question 7</strong></u></p>
<p>Why is it impossible to prevent the alcohol dehydrogenase enzymes from breaking down the ethylene glycol using competitive inhibitors when there is a high concentration of ethylene glycol in the body?</p>
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<p><label class="radio" data-answer="9860d09c1f087fbdd132581bf0701a75"><input type="radio"><span> There are so many molecules of ethylene glycol that it would require a dangerously high concentration of competitive inhiitor to effectively prevent the activity of alcohol dehydrogenase on ethylene glycol. </span></label></p>
<p><label class="radio" data-answer="82fcbe7dcab4873ea848fc1aace4f4a0"><input type="radio"><span> With a high concentration of ethylene glycol the alcohol dehydrogenase will be working too quickly</span></label></p>
<p><label class="radio" data-answer="6ced4ffc15cc730eea19a3d8d26cf265"><input type="radio"><span> There are so many molecules of ethylene glycol that none of the inhibitor molecules get to bind to the active site of alcohol dehydrogenase enzyme.</span></label></p>
<p><label class="radio" data-answer="d41d8cd98f00b204e9800998ecf8427e"><input type="radio"><span></span></label>With a high concentration of ethylene glycol the alcohol dehydrogenase will be working too quickly</p>
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$('img.ico[src="/img/icons/comments.png"]').each((function(){var t=$(this).attr("title");$(this).removeAttr("title"),$(this).wrap('<a class="tib-popover" href="#" data-content="'+t+'" data-togle="popover" data-placement="top" />')})),$('img.ico[src="img/icons/comments.png"]').each((function(){var t=$(this).attr("title");$(this).removeAttr("title"),$(this).wrap('<a class="tib-popover" href="#" data-content="'+t+'" data-togle="popover" data-placement="top" />')})),$(".tib-popover").popover({html:!0,trigger:"hover",delay:{show:300,hide:300},placement:function(t,e){var o=$(e).position();return o.top>200?"top":o.left<515?"right":o.top<200?"bottom":o.left>515?"left":"top"}}).click((function(t){t.preventDefault()}));var carouselTime=6500;$("div.carousel.slide").carousel({interval:carouselTime}),$(".tib-indicators > img").click((function(){var t=$(this).index(),e;$(this).closest(".carousel.slide").carousel(t)})),setShowResultsListeners($("#container")),addMarksThreads($("#modal-std-write"));
$('a.btn.showhider').click(function(e) {
var showHiderId = $( this ).attr('rel');
if( $('#'+showHiderId).find('iframe').length > 0 ) {
$('#'+showHiderId+' iframe').each(function() {
if ( $(this).attr('src').indexOf('.pdf') > 0 ) {
this.contentWindow.location.reload(true);
}
});
}
});
});
</script>
</body>
</html>